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12α,13‐Dihydroxyolean‐3‐oxo‐28‐oic acid, a New Triterpene, and the Known Oleanonic Acid as a New Cell Cycle Inhibitor from Schefflera venulosa
Author(s) -
Rui Liu,
QianQun Gu,
ChengBin Cui,
Bing Cai,
HongBing Liu,
Lei Wang,
HuaShi Guan
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200590242
Subject(s) - chemistry , triterpene , cell cycle , fractionation , stereochemistry , ic50 , cell , biochemistry , chromatography , in vitro , medicine , alternative medicine , pathology
12±,13‐Dihydroxyolean‐3‐oxo‐28‐oic acid ( 1 ), a new pentacyclic triterpene, was isolated from Schefflera venulosa (Wight et Arn.) Harms through a bioassay‐guided fractionation procedure, together with the known oleanonic acid ( 2 ) as a new cell cycle inhibitor. Structures were established by spectroscopy. Compound 2 inhibited the proliferation of K562 cells with the IC 50 value of 0.13 µmol/mL by the SRB method and inhibited the cell cycle of tsFT210 cells at the G 0 /G 1 phase at the concentration higher than 10 µg/mL.