12α,13‐Dihydroxyolean‐3‐oxo‐28‐oic acid, a New Triterpene, and the Known Oleanonic Acid as a New Cell Cycle Inhibitor from  Schefflera venulosa | Zendy

Rui Liu | Zendy; QianQun Gu | Zendy; ChengBin Cui | Zendy; Bing Cai | Zendy; HongBing Liu | Zendy; Lei Wang | Zendy; HuaShi Guan | Zendy

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12α,13‐Dihydroxyolean‐3‐oxo‐28‐oic acid, a New Triterpene, and the Known Oleanonic Acid as a New Cell Cycle Inhibitor from Schefflera venulosa

Author(s) -

Rui Liu,

QianQun Gu,

ChengBin Cui,

Bing Cai,

HongBing Liu,

Lei Wang,

HuaShi Guan

Publication year - 2005

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.200590242

Subject(s) - chemistry , triterpene , cell cycle , fractionation , stereochemistry , ic50 , cell , biochemistry , chromatography , in vitro , medicine , alternative medicine , pathology

12±,13‐Dihydroxyolean‐3‐oxo‐28‐oic acid ( 1 ), a new pentacyclic triterpene, was isolated from Schefflera venulosa (Wight et Arn.) Harms through a bioassay‐guided fractionation procedure, together with the known oleanonic acid ( 2 ) as a new cell cycle inhibitor. Structures were established by spectroscopy. Compound 2 inhibited the proliferation of K562 cells with the IC 50 value of 0.13 µmol/mL by the SRB method and inhibited the cell cycle of tsFT210 cells at the G 0 /G 1 phase at the concentration higher than 10 µg/mL.

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