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Synthesis and Pharmacological Activity of Annelated Pyrimidine Derivatives
Author(s) -
Aly A. A.
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200590211
Subject(s) - chemistry , pyrimidine , combinatorial chemistry , organic chemistry , stereochemistry
A series of 1‐glycosyl‐2‐glycosylthiopyrimidine ( 4 ), annelated pyrimidine derivatives, pyrazolo[3,4‐d]‐pyrimidine ( 8 ), ditetrazolo[1,5‐a;1′,5′‐c]pyrimidine ( 9 ), 2,9a,10‐triazaanthracene ( 12 ), thieno[2,3‐d]pyrimidine ( 14 ), 9‐thia‐1,3,5,7‐tetraazafluorene‐8‐one (15), 7‐oxa‐9‐thia‐1,3,5‐triazafluorene‐8‐one ( 16 ), 5‐oxa‐9‐thia‐1,3‐diaza‐fluorene ( 21a and 21b ) derivatives have been synthesized via a sequence of heterocyclization reactions of suitably functionalized 6‐[5‐(4‐bromophenyl)oxazol‐4‐yl]‐1,2,3,4‐tetrahydro‐2‐thioxo‐4‐oxopyrimidine‐5‐carbonitrile ( 2 ) with different electrophiles and nucleophiles. The new compounds were prepared with the objective to study their pharmacological properties