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Amino Acids Analysis by MALDI Mass Spectrometry Using Carbon Nanotube as Matrix
Author(s) -
Jing Zhang,
HaoYang Wang,
YinLong Guo
Publication year - 2005
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200590185
Subject(s) - chemistry , analyte , mass spectrometry , carbon nanotube , desorption , molecule , matrix (chemical analysis) , fragmentation (computing) , carbon fibers , matrix assisted laser desorption/ionization , analytical chemistry (journal) , chromatography , organic chemistry , nanotechnology , adsorption , materials science , composite number , computer science , composite material , operating system
Twenty common amino acids have been analyzed successfully by matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS) using carbon nanotubes as matrix. From the spectra, little or no background interference or fragmentation of the analytes has been observed. This method was also applied to the analysis of amino acid mixture successfully. Carbon nanotubes have some features such as large surface area to disperse the analyte molecules sufficiently and prevent the sample aggregation and strong ultraviolet absorption to transfer energy easily to the analyte molecules. The present method has potential application for the rapid and sensitive analysis of amino acids and their mixture