Synthesis of novel 1,3‐dioxolane nucleoside analogues | Zendy

Cai DongMei | Zendy; Lin KunHua | Zendy; Li MirtgZong | Zendy; Wen JiWu | Zendy; Li HongYan | Zendy; You TianPa | Zendy

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Synthesis of novel 1,3‐dioxolane nucleoside analogues

Author(s) -

Cai DongMei,

Lin KunHua,

Li MirtgZong,

Wen JiWu,

Li HongYan,

You TianPa

Publication year - 2004

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.20040221210

Subject(s) - chemistry , dioxolane , hydroxymethyl , nucleoside , thiazole , stereochemistry , nucleoside analogue , proton nmr , benzimidazole , organic chemistry

Novel 1,3‐dioxolane C‐nucleoside analogues of tiazofurin 2‐(2‐hydroxymethyl‐1,3‐dioxolan‐4‐yl)‐l,3‐thiazole‐4‐carboxamide as well as N ‐nucleoside analogues of substituted imidazoles 1‐(2‐hydroxymethyl‐1,3‐dioxolan‐4‐yl)‐4‐nitroimidazole and 1‐(2‐hydroxymethyl‐1,3‐dioxolan‐4‐yl)‐4,5‐dicyanoimidazole were synthesized from methyl acrylate through a multistep procedure. Their structures were confirmed by IR, 1 H NMR, 13 C NMR spectra and elemental analysis.

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