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A convenient preparation of N ‐Alkyl‐2,5‐dihydroisoxazoles from O ‐Allyl oximes
Author(s) -
Tang E,
Lin XiangJin,
Huang Xian
Publication year - 2004
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20040221027
Subject(s) - chemistry , iminium , alkyl , reagent , ring (chemistry) , medicinal chemistry , organic chemistry , catalysis
The organoselenium‐induced ring‐closure reaction of O ‐allyl oximes gave cyclic iminium salts, which reacted with Grignard reagents to produce N ‐alkyl‐4‐phenylselenoisoxazolidines. 2,5‐Dihydroisoxazoles could be obtained in good yields by subsequent selenoxide syn ‐elimination.
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