Extensive Studies on the AlEt 3 /THF‐promoted diastereoselective tandem rearrangement/reduction of α‐Hydroxy (amino) heterocyclopropane: An efficient approach to 2‐quaternary 1,3‐diheteroatom units | Zendy

Li Xin | Zendy; Wang BaoMin | Zendy; Zhao XueZhi | Zendy; Gao ShuanHu | Zendy; Tu YongQiang | Zendy; Li DeRun | Zendy

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Extensive Studies on the AlEt 3 /THF‐promoted diastereoselective tandem rearrangement/reduction of α‐Hydroxy (amino) heterocyclopropane: An efficient approach to 2‐quaternary 1,3‐diheteroatom units

Author(s) -

Li Xin,

Wang BaoMin,

Zhao XueZhi,

Gao ShuanHu,

Tu YongQiang,

Li DeRun

Publication year - 2004

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.20040221024

Subject(s) - chemistry , tandem , stereochemistry , epimer , substrate (aquarium) , quaternary , reduction (mathematics) , medicinal chemistry , combinatorial chemistry , oceanography , materials science , geometry , mathematics , composite material , geology , paleontology , biology

A facile and highly diastereoselective method for the construction of 2‐quaternary 1,3‐amino alcohols and 1,3‐diols has been developed on the basis of the AlEt 3 /THF‐promoted tandem rearrangement/reductive reaction of α‐hydroxy (amino) aziridines (epoxides). The progressive achievement in this article included that both 2‐epimers of the units could be constructed from the initially same substrate. Also a stereochemistry assignment we reported previously was corrected.

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