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Enantioseparation of novel chiral tetrahedral clusters on an amylose tris‐(3,5‐dimethylphenylcarbamate) chiral stationary phase by normal phase HPLC
Author(s) -
Li WenZhi,
Wang Xia,
Zhang WeiQiang,
LiRen Chen,
Li YongMin,
Ma ChunLin,
Yin YuanQi
Publication year - 2004
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20040221003
Subject(s) - chemistry , enantiomer , phase (matter) , high performance liquid chromatography , chiral column chromatography , tris , amylose , chromatography , silica gel , chiral resolution , tetrahedron , chiral derivatizing agent , crystallography , organic chemistry , starch , biochemistry
Amylose tris(3,5‐dimethylphenylcamate) (ADMPC) coated on a kind of small particle silica gel was prepared. On this ADMPC chiral stationary phase (CSP), the direct enantiomeric separation of six novel chiral transition metal tetrahedral clusters has firstly been achieved using n ‐hexane as the mobile phase containing various alcohols as modifiers. The effect of mobile phase modifiers and the structural variation of the solutes on their retention factors (k) and resolutions ( Rs ) were investigated. The result suggests that not only the structure and concentration of alcohol in mobile phase, but also the structural differences in racemates can have a pronounced effect on enantiomeric separation. ADMPC‐CSP is a suitable CSP for the optical resolution of chiral tetrahedral cluster by HPLC.