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Reaction of 2,3‐dihydro‐1,5‐benzothiazepines and phenylacetyl chloride in the presence of triethylamine: A new aspect on the formation mechanism of dihydro‐1,3‐oxazin‐4‐one derivatives
Author(s) -
Xu JiaXi,
Wang Chao,
Zhang QiHan
Publication year - 2004
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20040220927
Subject(s) - triethylamine , chemistry , medicinal chemistry , chloride , mechanism (biology) , organic chemistry , epistemology , philosophy
2a,CDisubstituted 2,2a,3,4‐tetrahydro‐2‐phenyl‐1 H ‐azeto[2,1‐ d ][1,5]benzothiazepin‐1‐ones, as well as 2‐substituted 2.3‐dihydro‐3‐phenylacetyl‐2‐styryl‐benzothiazoles and 4a,6‐disubstituted 3‐benzyl‐4a,5‐dihydro‐2‐phenyl1‐H,6H‐[1,3]oxazino[2,3‐d][1,5]benzothiazepin‐l‐ones, were obtained from the reaction of 2,4‐disubstituted 2,3dihydro‐1,5‐benzothiazepines with phenylacetyl chloride in the presence of triethylamine. The mechanism for the formation of 4a,5‐dihydro‐1 H ,6H‐[1,3]oxazino[2,3‐d][1,5]benzothiazepin‐1‐ones, 2,3‐dihydro‐1,3‐oxazin‐4‐one derivatives, was suggested.

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