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Theoretical study on the antioxidant activity of curcumin
Author(s) -
Sun YouMin,
Wang RuoXi,
Yuan ShiLing,
Lin XianJie,
Liu ChengBu
Publication year - 2004
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20040220812
Subject(s) - chemistry , curcumin , enol , antioxidant , moiety , molecule , intramolecular force , tautomer , hydrogen bond , photochemistry , dissociation (chemistry) , computational chemistry , organic chemistry , stereochemistry , catalysis , biochemistry
The computational results for curcumin at the B3LYP/6‐31G(d,p) level show that the enol form of curcumin is more stable than the diketo form because of an intramolecular hydrogen bond, which extends the conjugation effect in the enol chain, formed in the enol structure. Cis‐diketone form can not be obtained, presumably due to the strong repulsion between the carbonyl dipoles aligned h parallel. According to the phenolic OH bond dissociation enthalpy, curcumin in its most stable form can be suggested to be a relatively good antioxidant. In order to avoid overcoming H‐bond interaction and to improve the antioxidant activity of curcumin, a catechol moiety was incorporated into curcumin for designing a novel antioxidant. It is found that the designed molecule is much more efficient to scavenge radical than curcumin, comparable to vitamin E. Moreover, the ionization potential of the designed molecule is similar to that of curcumin, indicating that the designed molecule can not display the prooxidant effect.