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A novel reductive cyclization of o‐nitrobenzamides and ketones promoted by low‐valent titanium reagent
Author(s) -
Shi DaQing,
Rong LiangCe,
Wang JuXian,
Zhuang QiYa,
Tu ShuJianga
Publication year - 2004
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20040220725
Subject(s) - chemistry , reagent , titanium , elemental analysis , single crystal , combinatorial chemistry , reductive elimination , crystal structure , organic chemistry , crystallography , catalysis
A short and facile synthesis of a series of 1, 2‐dihydroquiazolin‐4(3H)‐ones was accomplished in good yields via novel reductive cyclization of o‐nitrobenzamides with ketones promoted by TiCl 4 /Zn system. The structure was established on the basis of elemental analysis, IR, 'H NMR and confirmed by a single‐crystal X‐ray diffraction analysis. This method has the advantages of easily accessible starting materials, convenient manipulation and moderate to high yields.