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Studies on the Physicochemical Properties, Structure and Antitumor Activity of an Oligosaccharide Homologue SnS‐2 from the Root of Scrophularia ningpoensis Hemsl
Author(s) -
Deng JunE,
Zhang Jian,
Chen XiaoMing,
Ke Wei,
Tian GengYuan
Publication year - 2004
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20040220520
Subject(s) - chemistry , oligosaccharide , chemical structure , gel permeation chromatography , chromatography , stereochemistry , organic chemistry , polymer
Abstract An oligosaccharide homologue named SnS‐2 was isolated from the root of Scrophularia ningpoensis Hemsl. SnS‐2 was purified by means of gel‐permeation chromatography and ion‐exchange chromatography. Its physico‐chemical properties, including carbohydrate content and molecular weight were determined. The structure of SnS‐2 was elucidated by chemical methods along with 1 H and 13 C NMR spectroscopy, including two‐dimensional DQCOSY and H‐detected 1 H, 13 C HMQC experiments. These. results show that SnS‐2 possesses a backbone consisting of terminal α‐Galp(1→, α‐Galp‐(1→6), α‐Glcp‐(1→6) and nonreducing end β‐Furf‐(2→. The bioactive assay showed that it could inhibit the growth of Lewis pulmonary carcinoma implanted in mice.