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Synthesis of Glutamic Acid‐based Cluster Galactosides and their Binding Affinities with Liver Cells
Author(s) -
Zhang XiaoRu,
Li YlngXia,
Chu ShiDong,
Ding Ning,
Li ChunXia,
Guan HuaShi
Publication year - 2004
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20040220518
Subject(s) - chemistry , affinities , galactosides , binding affinities , stereochemistry , in vitro , cluster (spacecraft) , amine gas treating , glutamic acid , galactose , biochemistry , combinatorial chemistry , amino acid , receptor , organic chemistry , computer science , programming language
Structurally well defined di‐, tri‐ and tetra‐valent cluster galactosides were synthesized in a convenient way. Oligo‐glutamic acids were assembled as scaffolds. The presence of amine groups in these three ligands is expected to couple with drugs or genes for delivery. The binding affinities of these cluster galactoses to liver cells were determined by in vitro binding studies. Among them. the tetravalent cluster galactose (19) showed the highest affinity to Liver cell. It is therefore a promising targeting device for the specific delivery of drugs or genes to parenchymal liver cells.