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Synthesis of Analogues of the Antitumor (1→6)‐Branched (1→3)‐Glucohexaose
Author(s) -
Zeng YouLin,
Zhang JianJun,
Kong FanZuo
Publication year - 2004
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20040220514
Subject(s) - chemistry , trisaccharide , acceptor , stereochemistry , physics , condensed matter physics
β‐D‐Glcp( 1→3)‐[β‐D‐Glcp‐( 1→6)‐/α‐D‐Manp‐( 1→3)‐β‐D‐Glcp( 1→3)‐[β‐D‐Glcp‐(1→6)‐] D ‐Glcp (18) and β‐D‐Glcp( 1→3)‐[β‐D‐Glcp‐( 1→6)‐] α‐D‐Manp‐( 1→3)‐β‐D‐Glcp‐( 1 →3)‐[β‐D‐Glcp‐( 1→6)‐]β‐D‐Glcp‐D‐(1→3)‐Glcp‐1→OMe (29) were synthesized as the analogues of the immunomodulator β‐D‐Glcp‐(1→3)‐[β‐D‐Glcp‐(1→6)‐]α‐D‐Glcp‐(1→3)‐β‐D‐Glcp‐(1→3)‐(β‐D‐Glcp‐(1→6)‐] D ‐Glcp through coupling of trisaccharide donors 9 with trisaccharide acceptor 16 and terrasaccharide acceptor 27 followed by deprotection. respectively.