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An Efficient Synthesis of [1, 2, 4]Triazolo[3, 2= d ][1, 5]benzoxazepin‐2‐thiones, a Kind of Novel Tricyclic O, N ‐Heterocycles
Author(s) -
Li Zheng,
Meng QingQing,
Wang QuanRui,
Tao FengGang
Publication year - 2004
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20040220316
Subject(s) - chemistry , tricyclic , d 1 , stereochemistry , combinatorial chemistry , medicinal chemistry , receptor , biochemistry
A series of novel tricyclic O, N ‐heterocycles, [1, 2, 4]triazolo[3.2‐ d ][1, 5]benzoxazepin‐2‐thiones 7 were achieved via acid‐induced ring closure of the geminal arylazo isothiocyanate compounds 5 which were derived from substituted chroman‐4‐ones. followed by feasible ring expansion with simultaneous insertion of the nitrogen atom into the carbon skeleton. The X‐ray crystal structure of 7d was also described.