Premium
Solid Phase Synthesis of 2‐Substituted 1 , 3‐Oxazin‐6‐ones Using Resin‐bound Cyclic Malonic Acid Ester
Author(s) -
Liu ZhanXiang,
Ruan XiuXiu,
Huang Xian
Publication year - 2004
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20040220222
Subject(s) - chemistry , malonic acid , acetoacetic ester synthesis , solid phase synthesis , phase (matter) , organic chemistry , medicinal chemistry , biochemistry , peptide
A facile solid phase. synthesis of 2‐substituted 1 ,3‐oxazin‐6‐ones using polymer‐supported Meldrum's acid has been reported. Reaction of the resin‐bound cyclic malonic acid ester with triethyl orthoformate and subsequent double substitution with amide, afforded the corresponding polymer‐supported acylaminomethylene cyclic malonic acid ester, which upon thermal treatment led to 1 , 3‐oxazin‐6‐ones in good yields and with high purity.