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Consecutive Reaction of Bis [2, 2, 2‐trifluoroethyl] phosphite. One‐pot Synthesis of Substituted 3‐Cyano‐β, γ‐unsaturated Nitriles with Exclusive or Predominant E‐ Selectivity
Author(s) -
Shen YanChang,
Zhang YuMing
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210737
Subject(s) - chemistry , selectivity , nitrile , medicinal chemistry , organic chemistry , catalysis
The consecutive reaction of bis [2, 2, 2‐trifluoroethyl] phosphite and its application to the one‐pot synthesis of 3‐cyano‐β, γ‐unsaturated nitriles with exclusive or predominant E ‐selectivity ( E:Z = 100–85:0—IS) and excellent yields (94%—99%) are described.