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Lipase‐Catalyzed Resolutions of both Enantiomers of Ornidazole and Secnidazole
Author(s) -
Tian Ping,
Peng JiaShi,
Li ZuYi,
Lin GuoQiang
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210727
Subject(s) - chemistry , ornidazole , enantiomer , lipase , acylation , catalysis , stereochemistry , organic chemistry , chromatography , enzyme
The resolutions of both enantiomers of the ornidazole and secnidazole were achieved with high enantiomeric excesses ( ee > 99%) by acylation of the corresponding racemates with vinylacetate in the presence of lipase Amano AK (from Pseudomonas sp. ). The assignments of the absolute configurations of (+) or (‐)‐ornidazole and secnidazole are described.