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Syntheses and Crystal Structure of Six‐coordinated Diorgnotin Complexes with 2, 5‐Dimercapto‐4‐phenyl‐1, 3,4‐thiodiazoIe
Author(s) -
Ma ChunLin,
Li Feng,
Zhang RuFen,
Wang DaQi
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210726
Subject(s) - chemistry , octahedron , stereochemistry , crystal structure , crystallography , potassium , salt (chemistry) , nmr spectra database , sequence (biology) , medicinal chemistry , spectral line , organic chemistry , biochemistry , physics , astronomy
The reactions of diorganotin dichloride [Ph 2 SnCl 2 , (PhCH 2 ) 2 ‐SnCl 2 or ( n ‐Bu) 2 SnCl 2 ] with potassium salt of 2, 5‐dimercapto‐4‐phenyl‐1, 3, 4‐thiodiazole gave complexes R 2 Sn (S 3 N 2 C 8 H 5 ) 2 (4: R = Ph; 5: R = PhCH 2 and 6: R = n ‐Bu), respectively. Characterizations were carried out for all complexes by IR, 1 H NMR spectra and X‐ray crystallography analysis. Including the Sn…N interaction, the three complexes all have six‐coordinated distorted octahedral geometry. Based on the requence of stereochemical constraint sequence, phenyl≈benzyl > n ‐butyl, the less the effect of the stereochemical constraint of R groups, the shorter the Sn…N length. In complexes 5 and 6, there exist S…S weak intra‐molecular interactions, through which the complexes are dissociated into loose 2D polymers. All three complexes show antitumour activity in bioactivity measurements.