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Syntheses of Two Potential Ligands for Tc‐99m Labeling as Diagnosis Agents of Alzheimer's Disease
Author(s) -
Zhuang ZhiPing,
Kung MeiPing,
Ono Masahiro,
Hou Catherine,
Kung Hank F.
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210722
Subject(s) - chemistry , biphenyl , bromine , wittig reaction , combinatorial chemistry , double bond , carbon atom , triple bond , stereochemistry , organic chemistry , ring (chemistry)
Abstract Two types of ligands‐biphenyl and stilbene derivatives, which can be labeled with Tc‐99m for the diagnosis of Alzheimer's disease (AD) have been synthesized successfully. The key steps in these two syntheses involved Suzuki reaction and Wittig reaction respectively. The new discovered debromination reaction may be expanded to the compounds with double or triple bond adjacent to the carbon atom bearing the bromine atoms. These types of syntheses provide a route to a series of biphenyl and stilbene derivatives that will benefit the search of new imaging agents for AD.