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A Facile Synthetic Method for the Preparation of s̀‐Symmetric (1, 2:4, 5)‐Diepoxypentane Equivalent
Author(s) -
Jiang Biao,
Chen ZiLi,
Shen Min,
Wang ZhiMin,
Shi Min
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210715
Subject(s) - chemistry , diastereomer , sharpless asymmetric dihydroxylation , optically active , natural product , diol , stereochemistry , dihydroxylation , combinatorial chemistry , organic chemistry , enantioselective synthesis , catalysis
Optically active s̀‐symmetric (1, 2:4, 5)‐diepoxypentane equivalent (10) has been synthesized in eight steps with moderate yields and diastereomeric excess by using Sharpless asymmetric dihydroxylation (AD reaction). Compound 10 can be used to prepare syn 1,3‐diol subunit in natural product.