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Mercaptolysis of the E/F Rings of Steroidal Sapogenins: A Concise Synthesis of Δ 20(22) ‐Furostene‐26‐thioethers
Author(s) -
Tian WeiSheng,
Guan HuiPing,
Pan XinFu
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210714
Subject(s) - sapogenin , chemistry , molecule , steroid , lewis acids and bases , stereochemistry , organic chemistry , catalysis , biochemistry , hormone , medicine , alternative medicine , pathology
Lewis acid catalyzed mercaptolysis of steroidal sapogenins was reinvestigated. Besides obtaining the reported 26‐thioacetals 5 under milder conditions, a new type of compounds Δ 20(22) ‐furostene‐26‐thioethers 6 were also synthesized through the mercaptolysis of steroidal sapogenins, which can be used to the synthesis of the steroidal molecule with side chains.