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Study on the Aggregation and Deaggregation Behaviors of Phosphatidylcholines
Author(s) -
Ji GuoZhen,
Long YaQiu,
Jiang XiKui
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210706
Subject(s) - chemistry , phospholipid , ether , phosphatidylcholine , membrane , organic chemistry , stereochemistry , biochemistry
Phosphatidylcholines and their analogs, the functional building block of the membrane, are recently found to mediate multiple physiological processes and exhibit a broad range of desirable pharmacological effects, which involve hydrophobic lipophilic interactions (HLI) between the phospholipid and the cell membrane. The HLI behavior of phosphatidylcholines (L n ) and their analogues 1, 2‐diacyl‐ sn ‐glycerol‐3‐phosphoric acid bromoethyl ester (P n ), have been investigated in MeOH‐H 2 O binary systems of different volume fractions (designated as ϕ) of the organic component, by employing α‐nephthylethyl lauryl ether (Np‐12) as fluorescent probe. A very interesting observation is that the L n possesses double character, i.e. , it behaves both as an aggregator and as a deaggregator. The effects of the structure and the environment on the coaggregation and deaggregation are also discussed.