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Synthesis and Antitumor Activity of Tanshinone Analogues
Author(s) -
Akber Aisa, Haji,
Lu Wd,
Cai JunChao
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210703
Subject(s) - chemistry , anisole , in vitro , mtt assay , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , catalysis
8,8‐Dimethyl‐5,6,7,8‐tetrahydrophenanthrene‐3,4‐dione (3) and 8,8‐dimethyl‐2‐(l‐hydroxy ethyl)‐5,6,7,8‐tetrahydrophenanthrene‐3,4‐dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P‐388 cell line as assayed by in vitro MTT method.