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One‐pot Synthesis of 3,4‐Dihydropyrimidin‐2(1 H )‐one Using TsOH as a Catalyst under Microwave Irradiation
Author(s) -
ShnJiang Tu,
Fang Fang,
ChunBao Miao,
Hong Jiang,
DaQing Shi
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210625
Subject(s) - chemistry , microwave irradiation , catalysis , urea , biginelli reaction , irradiation , microwave , organic chemistry , nuclear chemistry , physics , quantum mechanics , nuclear physics
A series of Biginelli compounds was synthesized using TsOH as a catalyst under microwave irradiation. This simple method provided the title compounds in 86%–98% yields by the reaction of aromatic aldehydes with 1,3‐carbonyl compound and urea. The structure of 4o was determined by single crystal X‐ray diffraction analysis.

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