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A Facile Solid Phase Synthesis of 2‐Alkylthio‐4(1 H )‐quinolones
Author(s) -
Jing Tang,
MingGuang Wu,
Xian Huang
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210522
Subject(s) - chemistry , halide , alkyl , isothiocyanate , aryl , medicinal chemistry , thiocarbamates , malonic acid , solid phase synthesis , phase (matter) , organic chemistry , peptide , biochemistry
The resin‐bound cyclic malonic add ester 2 reacted with aryl isothiocyanate and alkyl halides to afford the key intermediate arylthioaminomethylene cyclic malonic ester resin 3. Subsequently, resin 3 proceeded thermal cyclization giving the 2‐alkylthio‐4(1 H )‐quinolones in good yields and excellent purities.