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Synthesis and Insulin‐sensitizing Activity of a Series of 2‐Benzyl‐1,3‐dicarbonyl Derivatives
Author(s) -
Lei Tang,
Ying Leng,
HuoQuan Wang,
Ying Feng,
YuShe Yang,
RuYun Ji
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210402
Subject(s) - chemistry , insulin , in vivo , in vitro , series (stratigraphy) , combinatorial chemistry , biochemistry , medicine , microbiology and biotechnology , biology , paleontology
A series of 2‐benzyl‐1,3‐dicarbonyl derivatives was synthesized. Their insulin‐sensitizing activity was evaluated in 3T3‐L1 preadipocyte cells. Compounds 3, 26 and 27 were found to possess strong insulin‐sensitizing activity in vitro and were selected for further hypoglycemic evaluation in vivo .