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Synthesis of Novel Quinazoline Derivatives as Antimicrobial Agents
Author(s) -
Aly A. A.
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210324
Subject(s) - chemistry , nucleophile , quinazoline , isothiocyanate , organic chemistry , antimicrobial , phenyl isothiocyanate , yield (engineering) , cycloaddition , quinazolinone , amine gas treating , combinatorial chemistry , aryl , isocyanate , catalysis , materials science , alkyl , metallurgy , polyurethane
Quinazoline isothiocyanate 1 reacts with various nucleophiles (nitrogen nucleophiles, oxygen nucleophiles and sulphur nucleophiles) to afford heterocyclic systemes 2–13. Also, the [4 + 2] cycloaddition reaction of 1 with phenyl isocyanate, benzylidene aryl amine and cinnamic acid derivatives gave novel heterocyclic compounds 14–16. Moreover, the reaction of 1 with active methylene compounds under Michael reaction conditions also was investigated to yield 17 and 18 and it was found that all these reactions proceeded via isothiocyanate heterocyclization to furnish non‐condensed heterocyclic compounds. Some of the newly synthesized compounds were tested for their antimicrobial activities.