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Low‐valent Titanium Induced Intramolecular Reductive Coupling of Keto‐enamines: A Facile Synthesis of 2,3,5‐Trisubstituted Pyrroles
Author(s) -
XueSen Fan,
XinYing Zhang,
YongMin Zhang
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210323
Subject(s) - chemistry , intramolecular force , enamine , reagent , titanium , combinatorial chemistry , coupling (piping) , organic chemistry , catalysis , mechanical engineering , engineering
Abstract Promoted by low‐valent titanium reagent which was generated in situ from Sm/TiCl 4 system, keto‐enamine derivatives underwent efficient intromolecular deoxygenative coupling reactions and afforded the corresponding 2,3,5‐trisubstituted pyrroles in moderate to good yields under mild reaction conditions.