Premium
Chiral Ferrocenyl Amino Alcohols: Preparation and Application as Catalysts in the Enantioselective Reduction of Ketones Using NaBH 4 /I 2
Author(s) -
WdYi Chen,
Jun Lu,
ZongXuan Shen,
JianPing Lang,
LiFen Zhang,
YaWen Zhang
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210220
Subject(s) - chemistry , enantioselective synthesis , catalysis , moiety , enantiomer , organic chemistry , enantiomeric excess , amino acid , combinatorial chemistry , reducing agent , ferrocene , molecule , electrochemistry , biochemistry , electrode
Five novel chiral ferrocenyl amino alcohols were prepared from natural amino adds and used as catalysts in the asymmetric reduction of prochiral ketones with NaBH 4 /I 2 combination. The incorporation of the ferrocenyl moiety into the molecule of the chiral amino alcohols greatly improved their enantioselectivity in the catalysis. The optically active secondary alcohols were obtained in moderate to good enantiomeric excesses and high chemical yields.