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Novel Chiral Aminophosphine Ligand: Synthesis and Application in Asymmetric Catalytic Hydrogenation Reaction
Author(s) -
YiXin Chen,
YueMing Li,
KimHung Lam,
SunChi Chan Albert
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210116
Subject(s) - chemistry , catalysis , ligand (biochemistry) , asymmetric hydrogenation , biphenyl , rhodium , combinatorial chemistry , chiral ligand , solvent , enantioselective synthesis , medicinal chemistry , organic chemistry , receptor , biochemistry
A new chiral aminophosphine ligand 6,6′‐dimethoxy‐2,2′‐bis(diphenylphosphinoamino) biphenyl (DMBDPPABP) was prepared and its rhodium complex was found to be an effective catalyst for the asymmetric hydrogenation of amidoacrylic add and its derivatives. The effects of solvent and reaction temperature on enantioselectivity were also studied.