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Lipases‐Catalyzed Alcoholysis for the Preparation of Chiral 1‐ or 2‐Hydroxyalkanephosphonates
Author(s) -
YongHui Zhang,
JinFeng Li,
Ke Wang,
ChengYe Yuan
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210103
Subject(s) - chemistry , catalysis , optically active , organic chemistry , combinatorial chemistry , enantiomeric excess , lipase , enantioselective synthesis , enzyme
Abstract Enzymatic alcoholysis has been developed for the preparation of some chiral 1‐ and 2‐hydroxyalkanephosphonates with high optical purity. This method ensures the convenient access to the optically pure phosphocarnitine, phosphogabob and phosphomycin.