Premium
Synthesis of 2‐Benzylthio‐5‐phenyl‐3,4‐disubstituted Thiophenes by Intramolecular Condensation of α‐Oxo Ketene Dibenzyl‐thioacetals
Author(s) -
Wang Mang,
Ai Lin,
Zhang JiYu,
Liu Qun,
Gao LianXun
Publication year - 2002
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20020201223
Subject(s) - chemistry , ketene , intramolecular force , annulation , aldol condensation , sodium hydroxide , condensation , medicinal chemistry , catalysis , organic chemistry , combinatorial chemistry , physics , thermodynamics
A facile route to 2‐benzylthio‐5‐phenyl‐3,4‐disubstituted thiophenes was described. Catalyzed by sodium hydroxide, the title compounds were synthesized in moderate to good yields simply from the intramolecular aldol type condensation of α‐oxo ketene dibenzylthioacetals. The chemical selectivity for this annulation reaction was studied and discussed.