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Resonance Rayleigh Scattering Method for the Determination of Raloxifene with Evans Blue
Author(s) -
Fan Li,
Liu ShaoPu,
Yang DaCheng,
Hu XiaoLi
Publication year - 2002
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20020201217
Subject(s) - chemistry , rayleigh scattering , detection limit , hydrochloric acid , buffer solution , resonance (particle physics) , analytical chemistry (journal) , chromatography , inorganic chemistry , optics , physics , particle physics
The intensity of resonance Rayleigh scattering (RRS) of Evans blue (EB) or raloxifene hydrochloride (Ralo) is very weak, but it can be enhanced significantly and a new RRS spectrum appears when both of them interact to form an ion‐association complex in sodium acetate‐hydrochloric acid buffer solution at pH 1.8. The intensity of RRS is directly proportional to the concentration of Ralo in the range of 0–8.3 μg · mL −1 , and the detection limit for Ralo (σ = 3) is 18.9 ng·mL −1 . The method has high sensitivity and fairly good selectivity. Based on the above evidences, a new facile method for the determination of trace amount of Ralo has been established with satisfactory results.