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Studies on Synthesis and Intramolecular Catalyzed Hydrolysis of Thiophosphoramidate Derivatives of Nucleoside
Author(s) -
Miao ZhiWei,
Fu Hua,
Feng YuPing,
Han Bo,
Tu GuangZhong,
Zhao YuFen
Publication year - 2002
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20020201147
Subject(s) - chemistry , nucleoside , intramolecular force , prodrug , hydrolysis , serine , nucleotide , uridine , threonine , nucleoside analogue , catalysis , organic chemistry , stereochemistry , combinatorial chemistry , biochemistry , rna , enzyme , gene
Novel thiophosphoramidate derivatives of nucleoside analogue as membrane‐soluble prodrugs of the bioactive free nucleotides have been prepared by thiophosphorylation reaction. 2′,3′‐O, O ′‐Isopropylidene uridine‐5′‐yl N ‐thiophosphoryl serine and threonine methyl esters underwent the intramolecular catalyzed hydrolysis reaction.