Studies on Synthesis and Intramolecular Catalyzed Hydrolysis of Thiophosphoramidate Derivatives of Nucleoside | Zendy

Miao ZhiWei | Zendy; Fu Hua | Zendy; Feng YuPing | Zendy; Han Bo | Zendy; Tu GuangZhong | Zendy; Zhao YuFen | Zendy

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Studies on Synthesis and Intramolecular Catalyzed Hydrolysis of Thiophosphoramidate Derivatives of Nucleoside

Author(s) -

Miao ZhiWei,

Fu Hua,

Feng YuPing,

Han Bo,

Tu GuangZhong,

Zhao YuFen

Publication year - 2002

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.20020201147

Subject(s) - chemistry , nucleoside , intramolecular force , prodrug , hydrolysis , serine , nucleotide , uridine , threonine , nucleoside analogue , catalysis , organic chemistry , stereochemistry , combinatorial chemistry , biochemistry , rna , enzyme , gene

Novel thiophosphoramidate derivatives of nucleoside analogue as membrane‐soluble prodrugs of the bioactive free nucleotides have been prepared by thiophosphorylation reaction. 2′,3′‐O, O ′‐Isopropylidene uridine‐5′‐yl N ‐thiophosphoryl serine and threonine methyl esters underwent the intramolecular catalyzed hydrolysis reaction.

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