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Studies on Synthesis and Antitumor Activity of Phosphorylated Achyranthes bidentata Polysaccharide (P‐AbPS)
Author(s) -
Chen XiaoMing,
Zhang Jian,
Han GengYuan
Publication year - 2002
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20020201142
Subject(s) - chemistry , phosphorylation , formamide , polysaccharide , pyridine , solvent , phosphate , biochemistry , organic chemistry
The synthesis of phosphorylated Achyranthes bidentata polysaccharide (P‐AbPS) was reported based on different strategies. The P‐AbPS with high degree of substitution (D.S. > 0.5) was obtained when phosphorus oxychloride (POCl 3 ) was used as a phosphorylating agent and trimethyl phosphate‐pyridine or dimethyl formamide was used as solvent. The influences of different solvents and reaction conditions were discussed. The pharmacology assay shows that P‐AbPS possesses antitumor activity against sarcoma 180 and Lewis lung cancer in mice.