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Enzymatic Synthesis of Dipeptide Derivatives Containing Noncoded Amino Acids in Organic Solvents †
Author(s) -
Yang Hong,
Zhou Oiuang,
Tian GuiLing,
Ye YunHua
Publication year - 2002
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20020201133
Subject(s) - chemistry , dipeptide , amino acid , enzyme , peptide , organic chemistry , organic synthesis , organic solvent , peptide synthesis , stereochemistry , catalysis , biochemistry , chemical engineering , engineering
A series of dipeptide derivatives containing non‐coded amino acids, N ‐Boc‐4‐X‐Phe‐Ala‐NHNHPh (X = Cl, Br, I, NO 2 ), were synthesized by using thermoase in organic solvents. The physical data were consistent with the same samples prepared by 3‐(diethoxyphosphoryloxy)‐1, 2,3‐benzotriazin‐4 (3 H )‐one (DEPBT). Influence of different substituted groups of the noncoded amino acids and different organic solvents on the enzymatic peptide synthesis was studied.