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First Synthesis of Mosquito Larvicidal Butenolides I and II
Author(s) -
Jiang Sheng,
Wu YuLin,
Yao ZhuJim
Publication year - 2002
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20020200713
Subject(s) - chemistry , aldol condensation , enantiomer , aldol reaction , condensation , specific rotation , combinatorial chemistry , organic chemistry , stereochemistry , catalysis , physics , thermodynamics
Utilizing aldol condensation and β‐elimination as the key steps, butenolides I and II in excellent enantiomeric purity have been concisely synthesized for the first time. According to the rotation difference between synthetic samples and natural products, the rotations were corrected by the calculation upon HPLC measurements. In addition, an efficient way to synthesize methyl pentadec‐14‐enoate was developed.