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CoCl 2 ·6H 2 O or LaCl 3 ·7H 2 O Catalyzed Biginelli Reaction. One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1 H )‐ones
Author(s) -
Lu Jun,
Bai YinJuan,
Guo YanHong,
Wang ZhenJun,
Ma HuaiRang
Publication year - 2002
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20020200711
Subject(s) - chemistry , biginelli reaction , catalysis , urea , aldehyde , lanthanum , chloride , ethanol , cobalt , reaction conditions , nuclear chemistry , medicinal chemistry , organic chemistry
An efficient synthesis of 3,4‐dihydropyrimidinones from aldehyde, β‐keto ester and urea in ethanol using cobalt chloride hexahydrate or lanthanum chloride heptahydrate as a catalyst was described. Compared to the classical Biginelli reaction, this new method consistently has the advantage of good yields (56%‐99%) as well as short reaction time (4–5 h).