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Synthesis and Novel Properties of Alkyl Thiophosphoramidate Derivatives of Nucleosides
Author(s) -
Miao ZhlWei,
Fu Hua,
Tu GuangZhong,
Liu Hai,
Bo Han,
Zhao YuFen
Publication year - 2002
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20020200515
Subject(s) - chemistry , isopropyl , alkyl , nucleoside , intramolecular force , serine , hydrolysis , threonine , uridine , organic chemistry , stereochemistry , medicinal chemistry , biochemistry , rna , enzyme , gene
Novel alkyl thiophosphoramidate derivatives of nucleoside analogues (5) have been prepared by phosphochloridothioate chemistry. O ‐Isopropyl 2′, 3′‐ O ‐isopropylidene uridine‐5′‐yl N ‐thiophosphoryl threonine and serine methyl esters (Sa and 5b) underwent the intramolecular catalyzed hydrolysis reaction.
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