One‐Pot Syntheses of 3,4‐Dihydropyrimidine‐2 (1 H )‐thiones Catalyzed by La(OTf) 3 | Zendy

Chen RuiFang | Zendy; Qian ChangTao | Zendy

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One‐Pot Syntheses of 3,4‐Dihydropyrimidine‐2 (1 H )‐thiones Catalyzed by La(OTf) 3

Author(s) -

Chen RuiFang,

Qian ChangTao

Publication year - 2002

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.20020200505

Subject(s) - chemistry , thiourea , aldehyde , catalysis , condensation , organic chemistry , environmentally friendly , condensation reaction , medicinal chemistry , ecology , physics , biology , thermodynamics

A general and practical procedure for the syntheses of 3,4‐di‐hydropyrimidine‐2(1 H )‐thiones by a one‐pot condensation of aldehyde, β‐ketoester or β‐diketone and thiourea using La‐(OTf) 3 as the catalyst is described. Mild reaction conditions, excellent yields as well as the environmentally friendly character of La(OTf) 3 make it an important alternative to the classic acid‐catalyzed Biginelli's reaction.

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