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Synthesis and Antibacterial Activities of 4‐Amino‐3‐(1‐aryl‐5‐methyl‐1,2,3‐triazol‐4‐yl) ‐5‐mercapto‐1, 2,4‐triazoles/2‐ Amino‐5‐(1‐aryl‐5‐methyl‐1,2,3‐triazol‐4‐yl)‐1,3,4‐thiadiazoles and Their Derivatives
Author(s) -
Zhang Yan,
Sun XiaoWen,
Hui XinPing,
Zhang ZiYi,
Wang Qin,
Zhang Qi
Publication year - 2002
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20020200210
Subject(s) - chemistry , thiadiazoles , benzaldehyde , aryl , acetone , antibacterial activity , medicinal chemistry , proton nmr , organic chemistry , stereochemistry , bacteria , alkyl , biology , genetics , catalysis
Treatment of 4‐amino‐3‐(1‐aryl‐5‐methyl‐1,2,3‐triazol‐4‐yl)‐5‐mercapto‐1, 2,4‐triazoles/2‐amino‐5‐(1‐aryl‐5‐methyl‐1,2, 3‐triazol‐4‐yl)‐1,3,4‐thiadiazoles with benzaldehyde, acetone and ω‐bromoacetophenone was tested and compared. The title compounds Schiff bases, amides, imidazolo[2, 1‐ b ]‐1,3,4‐thiadiazoles and 7 H‐s ‐triazolo [3, 4‐ b ]‐1, 3, 4‐thiadiazines have been confirmed by elemental analyses, 1 H NMR, IR and MS spectra. All the compounds have also been screened for their antibacterial activities against B. subtilis, S. aureus and E. coli .

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