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Synthesis of 4‐fluoroalkyl‐2 H ‐pyrido [1, 2‐ a ] pyrimidin‐2‐ones from 2, 2‐dihydropolyfluoroalkanoic acids
Author(s) -
Lu HeJun,
Liu JinTao
Publication year - 2001
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20010191218
Subject(s) - chemistry , intramolecular force , fluorine , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry
In the presence of N, N′ ‐dicyclohexylcarbodiimide, 2‐aminopyridine and its derivatives (2) condensed with 2, 2‐di‐hydropolyfluoroalkanoic adds (1) to give the corresponding amides. Subsequent intramolecular Micheal addition‐elimination reactions of the fluorine‐containing amides under basic conditions gave 4‐fluoroalkyl‐2 H ‐pyrido[1,2‐ a ]pyrimidin‐2‐ones (3) in good yields.