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Synthesis and biological activity of l‐aminoindan‐l,3‐dicarboxylic acid, a benzo‐analogue of (1 S , 3 R )‐ACPD
Author(s) -
Ding Ke,
Zhang XinRong,
Ma DaWei,
Wang BaoMin
Publication year - 2001
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20010191212
Subject(s) - chemistry , stereochemistry , antagonist , agonist , acylation , intramolecular force , stereocenter , enantioselective synthesis , receptor , biochemistry , catalysis
Amino acids 1 and 2 were designed and synthesized as the conformationally constrained analogues of (1 S , 3 R )‐ or (1 S , 3 S )‐ACPDs, and the selective agonists of mGluRs. The synthesis started from ( R )‐phenylglycine using Seebach′s stereocenter self‐regeneration method and intramolecular acylation as key steps. No activity was found when 1 and 2 were tested as either mGluR agonist or antagonist.