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Low‐valent Titanium Induced Reductive Coupling of O ‐Nitrophenylazide with Benzoyl Substituted Ketene Dithioacetals: a Novel Synthesis of 4‐Aryl‐2‐methylthio‐3Z7‐l,5‐benzodiazepines
Author(s) -
Li ZhiFang,
Zhang YongMin
Publication year - 2001
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20010191016
Subject(s) - ketene , chemistry , aryl , titanium , medicinal chemistry , organic chemistry , alkyl
Treated with the low‐valent titanium derived from TiCl 4 /Sm system, o ‐nitrophenylazide could produce the intermediate 2 in situ , which reacted with benzoyl substituted ketene dithioacetals to afford 4‐aryl‐2‐methylthio‐3 H ‐1,5‐benzodiazepines in good yields under mild and neutral conditions.