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Novel Lanthanide Complexes of Ciprofloxacin : Synthesis, Characterization, Crystal Structure and in vitro Antibacterial Activity Studies
Author(s) -
Li JiaBin,
Yang Pin,
Gao Fei,
Han GaoYi,
Yu KaiBei
Publication year - 2001
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20010190611
Subject(s) - chemistry , lanthanide , triclinic crystal system , crystal structure , chelation , ligand (biochemistry) , antibacterial activity , crystallography , ciprofloxacin , stereochemistry , nuclear chemistry , ion , inorganic chemistry , organic chemistry , antibiotics , biochemistry , receptor , biology , bacteria , genetics
Novel lanthanide coordination compounds with ciprofloxacin (CPFX), including eleven complexes Ln(CPFX) 2 Cl(H 2 O), (Ln=Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb; n = 7, 8, 9) and crystalline [Ce(CPFX) 2 (H 2 O) 4 ] Cl (H 2 O) 3.25 (C 2 H 5 ‐OH) 0.25 , were synthesized. The crystal is of triclinic space group Pi with a = 1.3865(2) nm, b = 1.3899(3) nm, c = 1.6505(2) nm, a = 92.73(1)°, β= 114.39(1)°, γ=115.55 (1)°, Z = 2 and R = 0.0449. FT‐IR, electronic spectroscopy and X‐ray diffraction were employed to show that the lanthanide ion, which displays an eight‐coordinate structure, is chelated by 3‐carboxyl and 4‐keto oxygen donors of CPFX and two six‐membered chelate rings are formed. Test of in vitro antibacterial activity against E. coli, P. aeruginosa and S. aureus indicated that the in vitro antibacterial activity of the ligand can be improved by complexation with Ce(III).