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Synthesis of Benzofuran Analogue of Go6976, an Isoform‐Selective Protein Kinase C Inhibitor
Author(s) -
Ma DaWei,
Zhang YongDa,
Zhang XinRong,
Wu ShiHui,
Tao FengGang
Publication year - 2001
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20010190510
Subject(s) - chemistry , benzofuran , gene isoform , cyanation , intramolecular force , tryptamine , alkylation , stereochemistry , protein kinase c , combinatorial chemistry , kinase , biochemistry , catalysis , gene
Based on the structure of Go6976, a known isoform‐selective protein kinase C inhibitor, a benzofuran analogue (1) was designed. This analogue was synthesized by coupling of benzofuran 3‐acetic acid and 8‐oxo‐tryptamine and subsequent intramolecular Dieckmann condensation, alkylation, oxidative photocydization and cyanation reaction of mesylate.