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Synthesis and Hill Inhibitory Activity of New Substituted 3‐Aryl‐5‐cyano‐6‐methylthio Pyrimidine‐2, 4‐diones
Author(s) -
Liu HuaYin,
Hu FangZhong,
Yang HuaZheng
Publication year - 2001
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20010190414
Subject(s) - chemistry , pyrimidine , aryl , inhibitory postsynaptic potential , stereochemistry , proton nmr , medicinal chemistry , elemental analysis , organic chemistry , alkyl , neuroscience , biology
Novel substituted derivatives of 3‐aryl‐5‐cyano‐6‐methylthiopyrimidine‐2, 4‐diones were synthesized by the reaction of ethyl 2‐cyano‐3,3′‐dimethylthioacrylate with arylureas in good yields. The structures of all title compounds were evaluated by elemental analyses and 1 H NMR spectra and compound 2c was also confirmed by X‐ray diffraction. Hill reaction inhibitory activity of title compounds was assayed.