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Iotroridoside‐A, a Novel Cytotoxic Glycosphingolipid from the Marine Sponge Iotrochota ridley
Author(s) -
Deng SongZhi,
Tian ChunLei,
Xiao DingJun,
Wu HouMing
Publication year - 2001
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20010190408
Subject(s) - chemistry , sponge , glycosphingolipid , cytotoxicity , stereochemistry , cytotoxic t cell , two dimensional nuclear magnetic resonance spectroscopy , in vitro , biochemistry , botany , biology
A new cytotoxic glycosphingolipid, Iotroridoside‐A, was isolated from the marine sponge Iotrochota ridley collected from the South China Sea near Hainan Island, China. On the basis of chemical degradation method and IR, MS, 1 H NMR, 13 C NMR and 2D NMR spectrometry, its structure was assigned as 1‐ O ‐β‐D‐glucopyranosyl‐2‐[(4′ Z)‐2′‐hydroxytetracosene amido]‐4‐tetradecyl‐1, 3, 4‐butantriol. The new compound exhibits strong cytotoxicity against L1210 murine leukemia cells in vitro (ED 50 = 0.08 μg/mL).