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Syntheses, Crystal Structures and Cytotoxities of Silver (I) Complexes of 2,2′‐Bipyridines and 1,10‐Phenanthroline
Author(s) -
Zhu HaiLiang,
Chen Qi,
Peng WenLie,
Qi SuiJian,
Xu AnLong,
Chen XiaoMing
Publication year - 2001
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20010190310
Subject(s) - chemistry , denticity , acetonitrile , ligand (biochemistry) , crystallography , chelation , atom (system on chip) , phenanthroline , silver nitrate , single crystal , crystal structure , bipyridine , inorganic chemistry , organic chemistry , receptor , biochemistry , computer science , embedded system
The syntheses, characterizations and in vitro cytotoxities of seven soluble silver (I) compounds (1–7) with 2,2′‐bipyridine (bpy), 5,5′‐dimethyl‐2,2′‐bipyridine (dmbpy) and 1, 10‐phenanthroline (phen) are described. Two of the complexes, [Ag(dmbpy)(NO 3 )] (1) and [Ag(dmbpy)]ClO 4 (2), have been structurally established by single‐crystal X‐ray diffraction, which reveals the silver(I) atom in compound 1 is in a Y ‐shape coordination geometry with two N atoms ( av . AgN = 227.8 pm) from a chelate dmbpy ligand and an O atom (AgO=221.8(4) pm) from a monodentate nitrate. The Ag(I) atom in compound 2 is three‐coordinated by three N atoms, two of which are from a chelate dmbpy, and one from an acetonitrile ligand. The seven compounds showed strong cytotoxities in vitro to both normal and carcinoma cells.