Low‐Valent Titanium Induced Simultaneous Reduction of Nitro Group and SS Bond in Nitrodisulfides: A Facile Synthesis of 2 H ‐1,4‐Benzothiazines | Zendy

Zhang YongMin | Zendy; Zhong WeiHui | Zendy; Chen XiaoYian | Zendy

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Low‐Valent Titanium Induced Simultaneous Reduction of Nitro Group and SS Bond in Nitrodisulfides: A Facile Synthesis of 2 H ‐1,4‐Benzothiazines

Author(s) -

Zhang YongMin,

Zhong WeiHui,

Chen XiaoYian

Publication year - 2001

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.20010190214

Subject(s) - chemistry , nitro , reduction (mathematics) , titanium , group (periodic table) , double bond , medicinal chemistry , combinatorial chemistry , organic chemistry , alkyl , geometry , mathematics

The simultaneous reduction of nitro group and SS bond in nitrodisulfides by TiCl 4 /Sm system led to the active intermediates 2, which were “living” double‐anions in situ and reacted smoothly with ω‐bromoketones to afford the desired 2/7–1,4‐benzothiazines in good yields under mild and neutral conditions.

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