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Low‐Valent Titanium Induced Simultaneous Reduction of Nitro Group and SS Bond in Nitrodisulfides: A Facile Synthesis of 2 H ‐1,4‐Benzothiazines
Author(s) -
Zhang YongMin,
Zhong WeiHui,
Chen XiaoYian
Publication year - 2001
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20010190214
Subject(s) - chemistry , nitro , reduction (mathematics) , titanium , group (periodic table) , double bond , medicinal chemistry , combinatorial chemistry , organic chemistry , alkyl , geometry , mathematics
The simultaneous reduction of nitro group and SS bond in nitrodisulfides by TiCl 4 /Sm system led to the active intermediates 2, which were “living” double‐anions in situ and reacted smoothly with ω‐bromoketones to afford the desired 2/7–1,4‐benzothiazines in good yields under mild and neutral conditions.